張國軒醫師_著作論文 (第一作者/指導作者)

1.Chang KH, Lyu RK, Chen CM, Hsu WC, Wu YR, Chen ST, Ro LS. (2006). Clinical characteristics of multiple sclerosis in Taiwan: a cross-sectional study. Multple Sclerosis 12:501-6. (SCI)

2.Chang KH, Lyu RK, Ro LS, Wu YR (2006), Chen CM. Coexistence of Pernicious Anemia and Myasthenia Gravis—A Rare Combination of Autoimmune Diseases in Taiwan. J Formos Med Assoc 105: 946-949. (SCI)

3.Chang KH, Tan LM, Lyu RK (2006). Spontaneous Escherichia coli meningitis associated with hemophagocytic lymphohistiocytosis. J Formos Med Assoc 105: 756-759. (SCI)

4.Chang KH, Chuang CC, Lyu RK, Chen CM, Ro LS, Chen ST, Wu YR. Clinical Characteristics of Corticobasal Syndrome amongst Chinese in Taiwan (2007). Parkinsonism Rel Disord 13: 219-223. (SCI)

5.Chang KH, Lyu RK, Tseng MY, Ro LS, Wu YR, Chang HS, Hsu WC, Kuo HC, Huang CC, Chu CC, Hsieh SY, Chen CM (2007). Elevated haptoglobin level of cerebrospinal fluid in Guillain-Barre syndrome revealed by proteomics analysis. Proteomics- Clinical Applications 1: 467-475. (SCI)

6.Chang KH, Tsou JC, Chen ST, Ro LS, Lyu RK, Chang HS, Hsu WC, Chen CM, Wu YR, Chen CJ (2010). Temporal features of magnetic resonance imaging and spectroscopy in non-ketotic hyperglycemic chorea-ballism patients (2010). Eur J Neurol 17:489-493. (SCI)

7.Chang KH, Chuang TJ, Lyu RK, Ro LS, Wu YR, Chang HS, Huang CC, Kuo HC, Hsu WC, Chu CC, Chen CM (2012). Identification of Gene Networks and Pathways Associated with Guillain-Barré Syndrome. PLoS ONE 7: e29506 (SCI)

8.Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC, Kuo HC, Chu CC, Hsu WC, Ro LS (2013). Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies. Multiple Sclerosis 19: 299-307 (SCI)

9.Chen IC, Wu YR, Yang SJ, Kao SH, Chen YC, Chang KH, Lee CM, Lee-Chen GJ, Chen CM (2012). ATXN8-62 G/A promoter polymorphism and risk of Taiwanese Parkinson’s disease. Eur J Neurol 19: 1462-1469(SCI)

10.Chang KH, Chen YC, Wu YR, Lee WF, Chen CM (2012). Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington’s Disease Patients. PLoS One 7(9):e46492. (SCI)

11.Chang KH*, Li M (2013). Clonal Isolation of an Intermediate Pluripotent State. Stem Cells 31: 918-927 (SCI) (Corresponding author)

12.Chang KH, Tseng MY, Ro LS, Lyu RK, Tai YH, Chang HS, Wu YR, Huang CC, Hsu WC, Kuo HC, Chu CC, Chen CM (2013). Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis. Clinica Chimica Acta 417:26-30 (SCI).

13.Chang KH, Chen CM, Chen YC, Hsiao YC, Huang CC, Kuo HC, Hsu HC, Lee-Chen GJ, Wu YR (2013). Association between GRN rs5848 polymorphism and Parkinson’s disease in Taiwanese population. PLoS One 8(1):e54448 (SCI).

14.Chang KH, Chen WL, Lee LC, Lin CH, Kung PJ, Lin TH, Wu YC, Wu YR, Chen YC, Lee-Chen GJ, Chen CM (2013). Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3. Evidence-Based Complementary and Alternative Medicine 2013:471659 (SCI).

15.Chang KH, Chen CM, Chen YC, Lyu RK, Chang HS, Ro LS, Lee-Chen GJ, Wu YR (2013). Association between PARK16 and Parkinson’s disease in the Han-Chinese population: a meta-analysis. Neurobiology of Aging 34(10):2442.e5-9 (SCI)

16.Lyu RK, Chang KH, Chu CC, Kuo HC, Ro LS (2013). Sensory Conduction Study in Fisher Syndrome: Patterns of Abnormalities and Their Clinical Correlation. European Neurology 70: 27-32 (SCI)

17.Wu YR#, Chang KY#, Chang WT, Hsiao YC, Hsu HC, Chiang PR, Chen YC, Chao CY, Chang YC, Lee BH, Hu FJ, Chen WL, Lee-Chen GJ, Chen CM (2013). Genetic variants of LRRK2 in Taiwanese Parkinson’s disease. PLoS One 8(12):e82001. (SCI) (Co-first author)

18.Hung CH#, Chang KH#, Chu CC, Liao MF, Chang HS, Lyu RK, Wu YM, Chen YL, Lai CL, Tseng HJ, Ro LS. Painful ophthalmoplegia with normal cranial imaging. (2014). BMC Neurology 14:7 (SCI) (Co-first author)

19.Chang KH, Chen WL, Wu YR, Lin TH, Wu YC, Chao CY, Lin JY, Lee LC, Chen YC, Lee-Chen GJ, Chen CM. Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3. (2014). Neuropharmacology 81:166-175 (SCI)

20.Tsao WC, Lyu RK, Ro LS, Liao MF, Chen CM, Wu YR, Huang CC, Chang HS, Kuo HC, Chu CC, Chang KH*. Clinical correlations of motor and somatosensory evoked potentials in neuromyelitis optica. (2014). PLoS One 9(11):e113631 (SCI) (Corresponding author)

21.Chang KH, Ro LS, Lyu RK, Chen CM. Biomarkers for neuromyelitis optica (2015). Clinica Chimica Acta 440: 64-71 (SCI)

22.Liao MF, Chang KH*, Lyu RK, Huang CC, Chang HS, Wu YR, Chen CM, Chu CC, Kuo HC, Ro LS*. Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients (2015). BMC Neurol 14: 218 (SCI) (co-corresponding author)

23.Chang KH, Wu YR, Chen YC, Chen CM. Plasma Inflammatory biomarkers for Huntington’s disease patients and mouse model. (2015). Brain Behavior and Immunity 44: 121-127 (SCI).

24.Chang KH, Chiu YJ, Chen SL, Huang CH, Lin CH, Lin TH, Lee CM, Ramesh C, Wu CH, Huang CC, Fung HC, Chen YC, Lin JY, Yao CF, Huang HJ, Lee-Chen GJ, Lee MC, Hsieh-Li HM (2016). The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity. Neuropharmacology 101:309-319.

25.Chang KH, Wu YR, Chen YC, Fung HC, Lee-Chen GJ, Chen CM (2015). STK39, but not BST1, HLA-DQB1, and SPPL2B polymorphism, is associated with Han-Chinese Parkinson’s disease in Taiwan. Medicine (Baltimore). 94(41):e1690.

26.Chang KH, Wang SH, Chi CC (2015). Efficacy and safety of topiramate for essential tremor: a meta-analysis of randomized controlled trials. Medicine (Baltimore) 94(43):e1809.

27.Cheng ML, Chang KH, Wu YR, Chen CM (2016). Metabolic disturbances in plasma as biomarkers for Huntington’s disease. J Nutr Biochem 31: 38-44. (co-first author).

28.Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM (2016). The aqueous extract of Glycyrrhiza inflata can up-regulate UPR-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease. Drug Des Devel Ther 10: 885-896.

29.Chang KH*, Lee-Chen GJ, Wu YR, Chen YJ, Lin JL, Li M, Chen IC, Lo YS, Wu HC, Chen CM (2016). Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson’s disease. Parkinsonism Rel Disord 24: 81-88. (Corresponding author).

30.Chang, KH, Chen CM, Lin CH, Chang WT, Jiang PR, Hsiao YC, Yih-Ru Wu YR, Guey-Jen Lee-Chen GJ (2017). Functional properties of LRRK2 mutations in Taiwanese Parkinson’s disease. J Formos Med Assoc 116: 197-204.

31.Chang KH, Lin CH, Chen HC, Huang HY, Chen SL, Lin TH, Ramesh Chintakunta, Huang CC, Fung HC, Wu YR, Huang HJ, Lee-Chen GJ, Hsieh-Li HM, Yao CF (2017). The Potential of Indole/Indolylquinoline Compounds for Tau Misfolding Reduction by Enhancement of HSPB1. CNS Neurosci Ther 23(1): 45-56.

32.Chang KH, Lyu RK, Ro YS, Chen YC, Ro LS, Chang HS, Huang CC, Liao MF, Wu YR, Kuo HC, Chu CC, Chen CM (2016). Increased serum concentrations of transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barré syndrome. Clin Chim Acta 463: 8-13.

33.Chang CW, Wu HC, Lyu RK, Lo YS, Chen CM, Ro LS, Chang HS, Huang CC, Liao MF, Wu YR, Kuo HC, Chu CC, Weng YC, Wei PT, Lo AL, Chang KH*. (2018) Elevated serum levels of endothelin-1 in patients with chronic inflammatory demyelinating polyneuropathy. Clin Chim Acta 476: 49–53. (Corresponding author).

34.Chang KH, Wu YR, Chen CM (2017) Down-regulation of miR-9* in the peripheral leukocytes of Huntington’s disease patients. Orphanet J Rare Dis 12:185

35.Chang KH, Cheng ML, Tang HY, Huang CY, Wu YR, Chen CM (2018) Alternations of metabolic profile and kynurenine metabolism in the plasma of Parkinson’s disease. Mol Neurobiol 55(8):6319-6328.

36.Chang KH, Lee GC, Huang CC, Kuo HC, Chen CM, Hsiao YC, Hsu HC, Hsu KJ, Lin CH, Chang CW, Lee-Chen GJ, Wu YR. (2018) Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders. Parkinsonism Relat Disord. 51:61-66

37.Chang KH, Cheng ML, Chiang MC, Chen CM (2018). Lipophilic antioxidants in neurodegenerative diseases. Clin Chim Acta 485:79-87.

38.Chang KH*, Lee-Chen GJ, Huang CC, Lin JL, Chen YJ, Wei PC, Lo YS, Yao CF, Kuo MW, Chen CM (2019). Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation. Mol Neurobiol. 56:3972-3983. (Corresponding author)

39.Chang KH, Chen CM, Chen YC, Fung HC, Wu YR (2019) Polymorphisms of ACMSD-TMEM163, MCCC1 and BCKDK-STX1B are not associated with Parkinson’s disease in Taiwan. Parkinson’s Disease 2019: 3489638.

40.Lee SY, Chiu YJ, Yang SM, Chen CM, Huang CC, Lee-Chen GJ, Lin W, Chang KH (2018) Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection. CNS Neurosci Ther. 24(12):1286-1298. (Corresponding author)

41.Chen YC, Chiu YJ, Lin CH, Hsu WC, Wu JL, Huang CH, Lin CW, Yao CF, Huang HJ, Lo YS, Chen CM, Wu YR, Chang KH, Lee-Chen GJ, Mei Hsieh-Li H (2019) Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer’s Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement. J Alzheimers Dis. 67(2): 737-756. (Corresponding author)

42.Chiu YJ, Hsieh YH, Lin TH, Lee GC, Hsieh-Li HM, Sun YC, Chen CM, Chang KH, Lee-Chen GJ (2019) Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer’s disease. Neurochem Int. 125:175-186. (Corresponding author)

43.Chang KH, Lyu RK, Lin WT, Huang YT, Lin HS, Chang SH (2019). Gulllain-Barre Syndrome After Trivalent Influenza Vaccination in Adults. Front Neurol. 10:768.

44.Cheng YC, Chan YH, Hu CJ, Lu YC, Saek T, Hosoya M, Fujioka M, Okano H, Weng SM, Hsu CJ, Chang KH (2019). Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation. Stem Cell Res. 40L 101524 (Corresponding author)

45.Lin YY, Lee KY, Ro LS, Lo YS, Huang CC, Chang KH (2019). Clinical and cytokine profile of adult acute necrotizing encephalopathy. Biomed J. accepted (Corresponding author).

46.Chen IC#, Chang KH#, Chen YJ, Chen YC, Lee-Chen GU, Chen CM (2019). Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSCDerived Neurons. Oxid Med Cell Longev 2019: 8130481 (#Co-first author)

47.Wei PC, Lee-Chen GJ, Chen CM, Wu YR, Chen YJ, Lin JL, Lo YS, Yao CF and Chang KH (2019). Neuroprotection of indole-derivative compound NC001-8 by regulation of NRF2 pathway in Parkinson’s disease cell models Oxid Med Cell Longev. Accepted. 2019: 5074367 (Corresponding author)